Chronic wounds represent a major health challenge and place a substantial burden on healthcare systems. Current wound diagnosis and assessment methods rely largely on laboratory testing and often fail to capture the dynamic healing process. This project aims to design wearable sensors capable of continuously monitoring chronic wounds by performing wireless measurements of local pH and temperature, thereby reducing the need for frequent doctor visits and costly laboratory analyses.
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Saliva is a valuable, non-invasive biofluid that reflects a person’s physiological state and can provide rapid insights into health conditions. This project focuses on developing an intraoral bioelectronic platform for the real-time monitoring of clinical parameters in saliva, such as pH and other biomarkers of clinical interest. The device aims to enable continuous, non-invasive health monitoring and early detection of physiological imbalances. The project is held in collaboration with CNR-IEIIT.
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Dialysis is a life-sustaining treatment for patients with kidney failure, but it remains a complex and time-consuming process that requires frequent clinical supervision. Current approaches lack real-time monitoring of dialysate composition, limiting the ability to personalize and optimize therapy. This project aims to develop a urea sensor for continuous monitoring of urea levels in the dialysate, providing a reliable biomarker for treatment efficiency and patient health status.
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The CRISPR-Cas system, widely recognized for its revolutionary impact on gene editing, has also transformed biosensing due to its remarkable specificity and programmability, enabling tailored detection of target analytes. However, improving assay sensitivity typically requires a prior nucleic acid amplification step. This project aims to develop an autocatalytic amplification circuit in which activation of a few Cas/gRNA complexes, specifically designed for the target, triggers a secondary Cas/gRNA complex that amplifies the signal through a self-sustaining cascade, eliminating the need for separate amplification steps.
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